Who Owns SPYRE THERAPEUTICS INC (SYRE)? -- Institutional Holders (2026-06-30)

284 institutions reported holding $8.64B of SPYRE THERAPEUTICS INC (SYRE) in SEC 13F filings for 2026-06-30. Largest institutional holders: FMR LLC ($1.16B), BlackRock, Inc. ($577.7M), VANGUARD GROUP INC ($569.8M), PERCEPTIVE ADVISORS LLC ($383.5M), RTW INVESTMENTS, LP ($377.5M). Source: SEC Form 13F.

RankInstitutionValueSharesChange
1FMR LLC$1.16B13.0MAdded
2BlackRock, Inc.$577.7M6.5MAdded
3VANGUARD GROUP INC$569.8M6.4MAdded
4PERCEPTIVE ADVISORS LLC$383.5M4.3MAdded
5RTW INVESTMENTS, LP$377.5M4.3MAdded
6Paradigm Biocapital Advisors LP$341.0M3.8MAdded
7STATE STREET CORP$271.4M3.1MAdded
8VR ADVISER, LLC$265.0M3.0MTrimmed
9PRICE T ROWE ASSOCIATES INC /MD/$262.9M3.0MAdded
10Driehaus Capital Management LLC$248.5M2.8MAdded
11GEODE CAPITAL MANAGEMENT, LLC$239.3M2.6MAdded
12Capital World Investors$205.6M2.3MAdded
13Jupiter Topco LLC$195.9M2.2MNew
14TCG Crossover Management, LLC$168.7M1.9MHold
15TANG CAPITAL MANAGEMENT LLC$168.0M1.9MHold
16BANK OF AMERICA CORP /DE/$157.8M1.8MAdded
17ADAGE CAPITAL PARTNERS GP, L.L.C.$152.9M1.7MNew
18WELLINGTON MANAGEMENT GROUP LLP$140.4M1.6MTrimmed
19GOLDMAN SACHS GROUP INC$131.2M1.5MAdded
20FRANKLIN RESOURCES INC$130.8M1.5MAdded
21Remedium Capital Partners, LLC$130.0M1.5MAdded
22Affinity Asset Advisors, LLC$113.6M1.3MHold
23JPMORGAN CHASE & CO$98.9M1.1MAdded
24Holocene Advisors, LP$90.1M1.0MNew
25MARSHALL WACE, LLP$88.0M991,693Added

来源：SEC 13F 申报文件 · 截至 2026-06-30