5 insiders reported 15 Form 4 transactions for Upstream Bio, Inc. (UPB) over the past 18 months (most recent 2026-06-17). Recent activity: Ambrose Allison (General Counsel) Sell 477 shares, Sutherland Everett Rand (Chief Executive Officer) Sell 2,095 shares, Houghton Adam (Chief Business Officer) Sell 700 shares, Deykin Aaron (Chief Medical Officer) Sell 895 shares, GRAY MICHAEL (CFO and COO) Sell 853 shares. Source: SEC Form 4.
| Date | Insider | Title | Type | Shares | Value |
|---|---|---|---|---|---|
| 2026-06-17 | Ambrose Allison | General Counsel | Sell | 477 | $2,910 |
| 2026-06-17 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2,095 | $12,780 |
| 2026-06-17 | Houghton Adam | Chief Business Officer | Sell | 700 | $4,270 |
| 2026-06-17 | Deykin Aaron | Chief Medical Officer | Sell | 895 | $5,460 |
| 2026-06-17 | GRAY MICHAEL | CFO and COO | Sell | 853 | $5,203 |
| 2026-03-17 | GRAY MICHAEL | CFO and COO | Sell | 852 | $7,915 |
| 2026-03-17 | Houghton Adam | Chief Business Officer | Sell | 699 | $6,494 |
| 2026-03-17 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2,093 | $19,444 |
| 2026-03-17 | Ambrose Allison | General Counsel | Sell | 475 | $4,413 |
| 2026-03-17 | Deykin Aaron | Chief Medical Officer | Sell | 894 | $8,305 |
| 2026-01-06 | Houghton Adam | Chief Business Officer | Buy | 25,000 | $0 |
| 2026-01-06 | GRAY MICHAEL | CFO and COO | Buy | 30,500 | $0 |
| 2026-01-06 | Deykin Aaron | Chief Medical Officer | Buy | 32,000 | $0 |
| 2026-01-06 | Sutherland Everett Rand | Chief Executive Officer | Buy | 75,000 | $0 |
| 2026-01-06 | Ambrose Allison | General Counsel | Buy | 17,000 | $0 |
Source: SEC Form 4 filings · as of 2026-06-17