5 insiders reported 15 Form 4 transactions for Upstream Bio, Inc. (UPB) over the past 18 months (most recent 2026-06-17). Recent activity: GRAY MICHAEL (CFO and COO) Sell 853 shares, Sutherland Everett Rand (Chief Executive Officer) Sell 2,095 shares, Houghton Adam (Chief Business Officer) Sell 700 shares, Deykin Aaron (Chief Medical Officer) Sell 895 shares, Ambrose Allison (General Counsel) Sell 477 shares. Source: SEC Form 4.
| Date | Insider | Title | Type | Shares | Value |
|---|---|---|---|---|---|
| 2026-06-17 | GRAY MICHAEL | CFO and COO | Sell | 853 | $5,203 |
| 2026-06-17 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2,095 | $12,780 |
| 2026-06-17 | Houghton Adam | Chief Business Officer | Sell | 700 | $4,270 |
| 2026-06-17 | Deykin Aaron | Chief Medical Officer | Sell | 895 | $5,460 |
| 2026-06-17 | Ambrose Allison | General Counsel | Sell | 477 | $2,910 |
| 2026-03-17 | GRAY MICHAEL | CFO and COO | Sell | 852 | $7,915 |
| 2026-03-17 | Houghton Adam | Chief Business Officer | Sell | 699 | $6,494 |
| 2026-03-17 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2,093 | $19,444 |
| 2026-03-17 | Ambrose Allison | General Counsel | Sell | 475 | $4,413 |
| 2026-03-17 | Deykin Aaron | Chief Medical Officer | Sell | 894 | $8,305 |
| 2026-01-06 | Houghton Adam | Chief Business Officer | Buy | 25,000 | $0 |
| 2026-01-06 | GRAY MICHAEL | CFO and COO | Buy | 30,500 | $0 |
| 2026-01-06 | Deykin Aaron | Chief Medical Officer | Buy | 32,000 | $0 |
| 2026-01-06 | Sutherland Everett Rand | Chief Executive Officer | Buy | 75,000 | $0 |
| 2026-01-06 | Ambrose Allison | General Counsel | Buy | 17,000 | $0 |
Source: SEC Form 4 filings · as of 2026-06-17