Terminal · Institutions

Every 13F-reported equity position this quarter, with its quarter-over-quarter change — each row traces back to the SEC filing.

Opaleye Management Inc. 13F Holdings -- Portfolio & Top Positions (2026-03-31)

Opaleye Management Inc. (CIK 1595855) reported $759.2M across 51 reported positions in its SEC 13F filing for 2026-03-31. Largest positions: HROW ($99.9M, 13.15%), LQDA ($88.8M, 11.70%), ETON ($70.6M, 9.30%), SLGL ($39.6M, 5.22%), RYTM ($35.3M, 4.65%). Source: SEC Form 13F.

RankTickerCompanyValue% PortfolioSharesAction
1HROWHARROW INC$99.9M13.15%2.8MTrimmed
2LQDALIQUIDIA CORPORATION$88.8M11.70%2.5MAdded
3ETONETON PHARMACEUTICALS INC$70.6M9.30%2.9MHold
4SLGLSOL-GEL TECHNOLOGIES LTD$39.6M5.22%500,000Added
5RYTMRHYTHM PHARMACEUTICALS INC$35.3M4.65%123,000Trimmed
6APGEAPOGEE THERAPEUTICS INC$32.8M4.32%390,000Added
7IRONDISC MEDICINE INC$26.9M3.55%421,000Added
8URGNUROGEN PHARMA LTD$25.7M3.39%1.4MAdded
9CBIOCRESCENT BIOPHARMA INC.$24.1M3.18%1.3MAdded
10STOKSTOKE THERAPEUTICS INC$22.8M3.00%700,000Added
11CATXPERSPECTIVE THERAPEUTICS INC$19.5M2.57%4.7MAdded
12RZLTREZOLUTE INC$19.2M2.53%6.3MAdded
13MGTXMEIRAGTX HLDGS PLC$18.4M2.42%2.1MAdded
14TGTXTG THERAPEUTICS INC$17.8M2.34%535,000Hold
15SNWVSANUWAVE HEALTH INC$17.0M2.23%981,267Hold
16EWTXEDGEWISE THERAPEUTICS INC$15.8M2.07%500,000Hold
17ACOGALPHA COGNITION INC$14.1M1.85%2.6MAdded
18ANNXANNEXON INC$12.9M1.70%2.3MTrimmed
19ALMSALUMIS INC$12.1M1.60%550,000Added
20CDXSCODEXIS INC$11.1M1.46%6.8MTrimmed
21PTGXPROTAGONIST THERAPEUTICS INC$10.5M1.39%100,000Trimmed
22RVMDREVOLUTION MEDICINES INC$9.7M1.28%100,000Hold
23XOMAXOMA ROYALTY CORPORATION$9.4M1.24%300,000Added
24QTTBQ32 BIO INC$8.1M1.06%1.3MAdded
25MBXMBX BIOSCIENCES INC$7.8M1.02%260,000Hold

Source: SEC Form 13F filings · as of 2026-03-31