| 1 | RA CAPITAL MANAGEMENT, L.P. | $56.1M | 21.0M | Hold |
| 2 | Sands Capital Alternatives, LLC | $9.9M | 3.7M | Hold |
| 3 | BlackRock, Inc. | $6.6M | 2.5M | Added |
| 4 | Alyeska Investment Group, L.P. | $6.6M | 2.5M | Hold |
| 5 | FRANKLIN RESOURCES INC | $6.2M | 2.3M | Hold |
| 6 | VANGUARD GROUP INC | $6.1M | 2.3M | Added |
| 7 | ADAR1 Capital Management, LLC | $5.6M | 2.1M | Trimmed |
| 8 | Knollwood Investment Advisory, LLC | $4.3M | 1.6M | Hold |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | $3.0M | 1.1M | Added |
| 10 | Ikarian Capital, LLC | $2.8M | 1.1M | Hold |
| 11 | Hudson Bay Capital Management LP | $2.5M | 955,000 | Trimmed |
| 12 | Pathstone Holdings, LLC | $2.3M | 859,110 | Hold |
| 13 | RENAISSANCE TECHNOLOGIES LLC | $1.8M | 675,025 | Added |
| 14 | TWO SIGMA INVESTMENTS, LP | $1.7M | 622,882 | Added |
| 15 | STATE STREET CORP | $1.6M | 600,528 | Added |
| 16 | NORTHERN TRUST CORP | $963,187 | 360,744 | Added |
| 17 | DIMENSIONAL FUND ADVISORS LP | $778,969 | 291,559 | Added |
| 18 | BANK OF AMERICA CORP /DE/ | $733,665 | 274,781 | Trimmed |
| 19 | BOOTHBAY FUND MANAGEMENT, LLC | $728,942 | 273,012 | Hold |
| 20 | ACADIAN ASSET MANAGEMENT LLC | $718,000 | 270,338 | Added |
| 21 | NOMURA HOLDINGS INC | $506,531 | 189,712 | New |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $495,296 | 185,504 | Trimmed |
| 23 | GOLDMAN SACHS GROUP INC | $491,085 | 183,927 | Trimmed |
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | $470,377 | 176,171 | Hold |
| 25 | MORGAN STANLEY | $365,157 | 136,763 | Trimmed |