| 1 | BVF INC/IL | $54.5M | 19.8M | Hold |
| 2 | WELLS FARGO & COMPANY/MN | $2.8M | 1.0M | Trimmed |
| 3 | MILLENNIUM MANAGEMENT LLC | $2.2M | 792,657 | Trimmed |
| 4 | RENAISSANCE TECHNOLOGIES LLC | $1.7M | 624,367 | Trimmed |
| 5 | BlackRock, Inc. | $1.4M | 524,278 | Added |
| 6 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $1.1M | 405,658 | Added |
| 7 | DIMENSIONAL FUND ADVISORS LP | $1.1M | 390,165 | Added |
| 8 | CITADEL ADVISORS LLC | $820,141 | 298,233 | Added |
| 9 | Point72 Asset Management, L.P. | $806,300 | 293,200 | Trimmed |
| 10 | NORTHERN TRUST CORP | $765,911 | 278,513 | Trimmed |
| 11 | GROUP ONE TRADING LLC | $522,775 | 190,100 | Trimmed |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $433,846 | 157,762 | Trimmed |
| 13 | MARSHALL WACE, LLP | $361,511 | 131,458 | Trimmed |
| 14 | Dauntless Investment Group, LLC | $295,595 | 107,489 | Trimmed |
| 15 | UBS Group AG | $279,480 | 101,629 | Trimmed |
| 16 | ACADIAN ASSET MANAGEMENT LLC | $266,000 | 96,907 | Trimmed |
| 17 | MORGAN STANLEY | $245,446 | 89,253 | Trimmed |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | $174,902 | 63,601 | Hold |
| 19 | JANE STREET GROUP, LLC | $158,664 | 57,696 | Added |
| 20 | SIMPLEX TRADING, LLC | $149,655 | 54,420 | Added |
| 21 | TWO SIGMA INVESTMENTS, LP | $107,500 | 39,091 | Trimmed |
| 22 | GOLDMAN SACHS GROUP INC | $59,488 | 21,632 | Added |
| 23 | China Universal Asset Management Co., Ltd. | $49,093 | 17,852 | Added |
| 24 | BANK OF AMERICA CORP /DE/ | $47,952 | 17,437 | Trimmed |
| 25 | HRT FINANCIAL LP | $47,000 | 17,276 | New |