3 institutions reported holding $2.2M of SPYRE THERAPEUTICS INC (AGLE) in SEC 13F filings for 2026-06-30. Largest institutional holders: GROUP ONE TRADING LLC ($1.0M), HRT FINANCIAL LP ($887,000), SIMPLEX TRADING, LLC ($248,584). Source: SEC Form 13F.
| Rank | Institution | Value | Shares | Change |
|---|---|---|---|---|
| 1 | GROUP ONE TRADING LLC | $1.0M | 11,800 | Added |
| 2 | HRT FINANCIAL LP | $887,000 | 10,000 | New |
| 3 | SIMPLEX TRADING, LLC | $248,584 | 2,800 | New |
Source: SEC Form 13F filings · as of 2026-06-30