| 1 | Cormorant Asset Management, LP | $45.7M | 4.0M | Added |
| 2 | VR ADVISER, LLC | $36.9M | 3.2M | Hold |
| 3 | Balyasny Asset Management L.P. | $35.2M | 3.1M | Added |
| 4 | Point72 Asset Management, L.P. | $24.6M | 2.1M | New |
| 5 | MPM BIOIMPACT LLC | $22.3M | 1.9M | New |
| 6 | PERCEPTIVE ADVISORS LLC | $20.6M | 1.8M | New |
| 7 | Casdin Capital, LLC | $14.4M | 1.2M | Added |
| 8 | ADAR1 Capital Management, LLC | $11.7M | 1.0M | Added |
| 9 | Octagon Capital Advisors LP | $10.7M | 934,716 | New |
| 10 | MILLENNIUM MANAGEMENT LLC | $9.3M | 807,832 | Added |
| 11 | BRAIDWELL LP | $9.1M | 795,214 | New |
| 12 | Squadron Capital Management LLC | $8.8M | 764,876 | Trimmed |
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | $8.3M | 718,747 | New |
| 14 | SUPERSTRING CAPITAL MANAGEMENT LP | $6.4M | 552,501 | Added |
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $6.2M | 538,461 | Hold |
| 16 | Woodline Partners LP | $5.2M | 455,733 | Added |
| 17 | Soleus Capital Management, L.P. | $4.7M | 405,523 | New |
| 18 | Freestone Grove Partners LP | $4.6M | 397,446 | New |
| 19 | BOONE CAPITAL MANAGEMENT LLC | $3.0M | 258,390 | New |
| 20 | DAFNA Capital Management LLC | $2.8M | 239,553 | New |
| 21 | Kalehua Capital Management LLC | $2.6M | 226,415 | New |
| 22 | Affinity Asset Advisors, LLC | $1.8M | 153,847 | Trimmed |
| 23 | Seven Fleet Capital Management LP | $1.3M | 113,207 | New |
| 24 | DV Trading LLC | $1.3M | 113,207 | New |
| 25 | RENAISSANCE TECHNOLOGIES LLC | $1.1M | 94,100 | Added |