| 1 | BlackRock, Inc. | $1.14B | 18.2M | Trimmed |
| 2 | Avoro Capital Advisors LLC | $670.9M | 10.7M | Added |
| 3 | FMR LLC | $463.0M | 14.4M | Added |
| 4 | VANGUARD PORTFOLIO MANAGEMENT LLC | $448.1M | 7.1M | New |
| 5 | STATE STREET CORP | $421.5M | 20.2M | Added |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | $378.2M | 6.0M | New |
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | $305.8M | 201.6M | Added |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | $274.5M | 4.3M | Added |
| 9 | FRED ALGER MANAGEMENT, LLC | $209.6M | 3.3M | Added |
| 10 | Invesco Ltd. | $209.1M | 6.5M | Added |
| 11 | Vestal Point Capital, LP | $142.6M | 2.3M | Added |
| 12 | BAKER BROS. ADVISORS LP | $124.9M | 2.0M | Trimmed |
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $115.1M | 1.8M | Added |
| 14 | GOLDMAN SACHS GROUP INC | $112.2M | 4.7M | Added |
| 15 | NORTHERN TRUST CORP | $103.8M | 1.7M | Added |
| 16 | Siren, L.L.C. | $101.3M | 1.6M | Added |
| 17 | Linden Advisors LP | $95.8M | 92.4M | New |
| 18 | JANUS HENDERSON GROUP PLC | $90.1M | 1.4M | Added |
| 19 | UBS Group AG | $88.1M | 5.5M | Added |
| 20 | UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | $83.5M | 1.3M | Added |
| 21 | Pictet Asset Management Holding SA | $79.6M | 1.3M | Added |
| 22 | D. E. Shaw & Co., Inc. | $74.8M | 1.2M | Added |
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $74.7M | 1.2M | Trimmed |
| 24 | Driehaus Capital Management LLC | $74.6M | 1.2M | Trimmed |
| 25 | Fisher Asset Management, LLC | $69.8M | 1.1M | Trimmed |