| 1 | FMR LLC | $43.0M | 2.9M | Added |
| 2 | T. Rowe Price Investment Management, Inc. | $32.3M | 2.2M | New |
| 3 | Caligan Partners LP | $24.4M | 1.6M | Added |
| 4 | BVF INC/IL | $24.4M | 1.6M | Added |
| 5 | Avoro Capital Advisors LLC | $21.1M | 1.4M | New |
| 6 | Affinity Asset Advisors, LLC | $20.0M | 1.3M | Added |
| 7 | Logos Global Management LP | $19.4M | 1.3M | New |
| 8 | Nantahala Capital Management, LLC | $18.4M | 1.2M | Hold |
| 9 | UBS Group AG | $17.0M | 1.1M | Added |
| 10 | Caption Management, LLC | $16.2M | 1.1M | Added |
| 11 | Point72 Asset Management, L.P. | $13.7M | 916,142 | Added |
| 12 | FARALLON CAPITAL MANAGEMENT LLC | $13.7M | 916,000 | New |
| 13 | RTW INVESTMENTS, LP | $12.8M | 856,962 | New |
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $12.8M | 854,000 | Added |
| 15 | MILLENNIUM MANAGEMENT LLC | $12.5M | 835,484 | Added |
| 16 | TCG Crossover Management, LLC | $11.0M | 738,383 | Added |
| 17 | Balyasny Asset Management L.P. | $10.9M | 731,586 | Added |
| 18 | VANGUARD CAPITAL MANAGEMENT LLC | $10.7M | 719,694 | New |
| 19 | RA CAPITAL MANAGEMENT, L.P. | $9.9M | 662,968 | Hold |
| 20 | BANK OF AMERICA CORP /DE/ | $9.6M | 643,000 | Added |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9.5M | 637,200 | Added |
| 22 | Seven Fleet Capital Management LP | $8.6M | 573,883 | Added |
| 23 | Ikarian Capital, LLC | $8.4M | 560,000 | Added |
| 24 | BOOTHBAY FUND MANAGEMENT, LLC | $7.3M | 485,758 | Added |
| 25 | Commodore Capital LP | $7.2M | 483,000 | Hold |