| 1 | FMR LLC | $234.3M | 9.0M | Added |
| 2 | Fairmount Funds Management LLC | $225.7M | 8.7M | New |
| 3 | Avoro Capital Advisors LLC | $98.0M | 3.8M | New |
| 4 | VR ADVISER, LLC | $93.3M | 3.6M | New |
| 5 | FCPM III SERVICES B.V. | $63.2M | 2.4M | New |
| 6 | RA CAPITAL MANAGEMENT, L.P. | $62.1M | 2.4M | New |
| 7 | JANUS HENDERSON GROUP PLC | $61.4M | 2.4M | Added |
| 8 | VIKING GLOBAL INVESTORS LP | $59.9M | 2.3M | New |
| 9 | Bellevue Group AG | $59.5M | 2.3M | New |
| 10 | Remedium Capital Partners, LLC | $53.0M | 2.0M | Added |
| 11 | Commodore Capital LP | $50.2M | 1.9M | New |
| 12 | Cormorant Asset Management, LP | $39.5M | 1.5M | New |
| 13 | Balyasny Asset Management L.P. | $37.5M | 1.4M | New |
| 14 | a16z Capital Management, L.L.C. | $32.0M | 1.2M | New |
| 15 | PERCEPTIVE ADVISORS LLC | $31.7M | 1.2M | New |
| 16 | Point72 Asset Management, L.P. | $30.9M | 1.2M | Added |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | $27.4M | 1.1M | New |
| 18 | Siren, L.L.C. | $23.3M | 900,000 | New |
| 19 | BRAIDWELL LP | $23.2M | 894,846 | New |
| 20 | Vestal Point Capital, LP | $15.5M | 600,000 | New |
| 21 | Blackstone Inc. | $13.0M | 503,522 | New |
| 22 | MILLENNIUM MANAGEMENT LLC | $12.2M | 471,646 | New |
| 23 | Affinity Asset Advisors, LLC | $11.7M | 450,000 | New |
| 24 | Ikarian Capital, LLC | $8.7M | 335,710 | Added |
| 25 | Qube Research & Technologies Ltd | $7.3M | 282,436 | New |