| 1 | WELLINGTON MANAGEMENT GROUP LLP | $164.5M | 29.7M | Trimmed |
| 2 | RTW INVESTMENTS, LP | $146.8M | 4.9M | Hold |
| 3 | FMR LLC | $145.6M | 4.8M | Added |
| 4 | PRIMECAP MANAGEMENT CO/CA/ | $111.4M | 3.7M | Trimmed |
| 5 | Bellevue Group AG | $84.3M | 2.8M | Hold |
| 6 | Vestal Point Capital, LP | $83.4M | 2.8M | Added |
| 7 | Linden Advisors LP | $81.9M | 90.8M | Hold |
| 8 | TANG CAPITAL MANAGEMENT LLC | $79.9M | 2.6M | Added |
| 9 | Context Capital Management, LLC | $70.2M | 77.8M | Added |
| 10 | Caption Management, LLC | $58.3M | 1.9M | Added |
| 11 | Deep Track Capital, LP | $58.2M | 1.9M | Trimmed |
| 12 | T. Rowe Price Investment Management, Inc. | $57.0M | 1.9M | Trimmed |
| 13 | Logos Global Management LP | $45.2M | 1.5M | Added |
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | $43.5M | 18.4M | Trimmed |
| 15 | BVF INC/IL | $39.0M | 1.3M | Trimmed |
| 16 | CAMDEN ASSET MANAGEMENT L P /CA | $38.3M | 42.7M | Added |
| 17 | MILLENNIUM MANAGEMENT LLC | $37.3M | 1.2M | Added |
| 18 | ARMISTICE CAPITAL, LLC | $35.8M | 1.2M | Added |
| 19 | Point72 Asset Management, L.P. | $33.2M | 1.1M | Added |
| 20 | Fiera Capital Corp | $32.6M | 1.1M | Added |
| 21 | TWO SIGMA INVESTMENTS, LP | $30.8M | 1.0M | Added |
| 22 | DEERFIELD MANAGEMENT COMPANY, L.P. | $27.0M | 30.0M | Hold |
| 23 | Kynam Capital Management, LP | $26.7M | 884,937 | Added |
| 24 | BlackRock, Inc. | $25.5M | 7.0M | Added |
| 25 | BAKER BROS. ADVISORS LP | $22.1M | 734,397 | Trimmed |