| 1 | Aberdeen Group plc | $12.7M | 824,393 | Trimmed |
| 2 | BVF INC/IL | $11.8M | 765,295 | Trimmed |
| 3 | MILLENNIUM MANAGEMENT LLC | $11.4M | 740,347 | Trimmed |
| 4 | Avidity Partners Management LP | $10.3M | 669,941 | Trimmed |
| 5 | VANGUARD GROUP INC | $10.1M | 656,776 | Trimmed |
| 6 | BRAIDWELL LP | $9.9M | 645,010 | New |
| 7 | Laurion Capital Management LP | $9.4M | 610,326 | Trimmed |
| 8 | Jones Hill Capital LP | $8.3M | 539,814 | New |
| 9 | Woodline Partners LP | $7.2M | 471,528 | Trimmed |
| 10 | Soleus Capital Management, L.P. | $6.9M | 450,000 | Trimmed |
| 11 | Propel Bio Management, LLC | $5.0M | 325,022 | Trimmed |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4.0M | 259,690 | Trimmed |
| 13 | Nantahala Capital Management, LLC | $3.9M | 250,646 | Trimmed |
| 14 | UBS Group AG | $2.7M | 175,756 | Trimmed |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $2.6M | 170,675 | Trimmed |
| 16 | 683 Capital Management, LLC | $2.3M | 147,245 | Trimmed |
| 17 | SIMPLEX TRADING, LLC | $2.2M | 145,800 | Trimmed |
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.1M | 139,860 | Trimmed |
| 19 | BlackRock, Inc. | $2.0M | 132,791 | Trimmed |
| 20 | JANE STREET GROUP, LLC | $1.6M | 104,987 | Trimmed |
| 21 | MARSHALL WACE, LLP | $1.6M | 104,816 | Trimmed |
| 22 | Jefferies Financial Group Inc. | $1.3M | 84,900 | New |
| 23 | Ikarian Capital, LLC | $1.0M | 67,464 | Trimmed |
| 24 | Quadrature Capital Ltd | $580,771 | 37,786 | Added |
| 25 | CITADEL ADVISORS LLC | $543,790 | 35,380 | Trimmed |