| 1 | JANUS HENDERSON GROUP PLC | $42.9M | 33.1M | Added |
| 2 | PERCEPTIVE ADVISORS LLC | $27.1M | 20.9M | Trimmed |
| 3 | BVF INC/IL | $25.4M | 19.5M | Hold |
| 4 | MAVERICK CAPITAL LTD | $24.7M | 19.0M | Hold |
| 5 | Saturn V Capital Management LP | $14.2M | 10.9M | Added |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | $13.1M | 10.1M | New |
| 7 | M28 Capital Management LP | $12.0M | 9.2M | Hold |
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | $11.8M | 9.1M | Added |
| 9 | Driehaus Capital Management LLC | $11.0M | 8.4M | Trimmed |
| 10 | Soleus Capital Management, L.P. | $10.0M | 7.7M | Hold |
| 11 | STATE STREET CORP | $9.0M | 6.9M | Added |
| 12 | BlackRock, Inc. | $5.6M | 4.3M | Added |
| 13 | Siren, L.L.C. | $5.2M | 4.0M | Hold |
| 14 | ADAR1 Capital Management, LLC | $5.0M | 3.8M | Trimmed |
| 15 | STEMPOINT CAPITAL LP | $4.9M | 3.7M | Added |
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $4.8M | 3.7M | Hold |
| 17 | Balyasny Asset Management L.P. | $4.6M | 3.5M | Trimmed |
| 18 | MILLENNIUM MANAGEMENT LLC | $4.6M | 3.5M | Added |
| 19 | MORGAN STANLEY | $4.4M | 3.4M | Added |
| 20 | Qube Research & Technologies Ltd | $3.5M | 2.7M | Added |
| 21 | Ikarian Capital, LLC | $3.5M | 2.7M | Hold |
| 22 | Redmile Group, LLC | $3.4M | 2.6M | Trimmed |
| 23 | GOLDMAN SACHS GROUP INC | $3.4M | 2.6M | Added |
| 24 | 683 Capital Management, LLC | $3.3M | 2.5M | Trimmed |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | $3.2M | 2.5M | Added |