| 1 | BAKER BROS. ADVISORS LP | $776.1M | 19.9M | Hold |
| 2 | BlackRock, Inc. | $161.1M | 4.1M | Added |
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | $126.6M | 3.2M | Added |
| 4 | VANGUARD GROUP INC | $104.9M | 2.7M | Added |
| 5 | STATE STREET CORP | $94.3M | 2.4M | Added |
| 6 | GOLDMAN SACHS GROUP INC | $90.2M | 2.3M | Added |
| 7 | BRAIDWELL LP | $69.6M | 1.8M | Trimmed |
| 8 | Jupiter Topco LLC | $59.5M | 1.5M | New |
| 9 | RTW INVESTMENTS, LP | $58.0M | 1.5M | Hold |
| 10 | Boxer Capital Management, LLC | $57.6M | 1.5M | Added |
| 11 | T. Rowe Price Investment Management, Inc. | $57.5M | 1.5M | Added |
| 12 | TCG Crossover Management, LLC | $56.3M | 1.4M | Hold |
| 13 | Ikarian Capital, LLC | $49.8M | 1.3M | Trimmed |
| 14 | ICONIQ Capital, LLC | $49.3M | 1.3M | Hold |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $41.4M | 1.1M | Added |
| 16 | Artisan Partners Limited Partnership | $37.7M | 968,037 | Added |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | $30.9M | 793,613 | Added |
| 18 | Board of Trustees of The Leland Stanford Junior University | $27.0M | 691,767 | Hold |
| 19 | DIADEMA PARTNERS LP | $21.9M | 561,717 | Added |
| 20 | SILVERARC CAPITAL MANAGEMENT, LLC | $21.3M | 546,256 | Trimmed |
| 21 | Squadron Capital Management LLC | $19.5M | 500,000 | Added |
| 22 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $19.5M | 500,000 | Trimmed |
| 23 | TWO SIGMA INVESTMENTS, LP | $18.4M | 473,001 | Added |
| 24 | MORGAN STANLEY | $16.9M | 435,029 | Trimmed |
| 25 | BANK OF AMERICA CORP /DE/ | $14.9M | 383,709 | Added |