| 1 | RA CAPITAL MANAGEMENT, L.P. | $18.7M | 1.9M | Hold |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $14.9M | 1.5M | Trimmed |
| 3 | ACORN CAPITAL ADVISORS, LLC | $14.8M | 1.5M | Added |
| 4 | GOLDMAN SACHS GROUP INC | $13.9M | 1.4M | Added |
| 5 | BlackRock, Inc. | $13.9M | 1.4M | Added |
| 6 | VANGUARD GROUP INC | $12.2M | 1.2M | Added |
| 7 | Catalio Capital Management, LP | $9.2M | 940,855 | Added |
| 8 | Avidity Partners Management LP | $9.0M | 924,487 | Added |
| 9 | T. Rowe Price Investment Management, Inc. | $7.7M | 786,309 | Trimmed |
| 10 | TWO SIGMA INVESTMENTS, LP | $6.8M | 695,264 | Added |
| 11 | Kalehua Capital Management LLC | $6.7M | 685,644 | New |
| 12 | NEA Management Company, LLC | $5.6M | 576,780 | New |
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5.3M | 545,700 | Trimmed |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | $5.2M | 531,231 | Added |
| 15 | Ghisallo Capital Management LLC | $4.9M | 500,000 | New |
| 16 | Soleus Capital Management, L.P. | $4.3M | 440,000 | Hold |
| 17 | Caption Management, LLC | $3.7M | 378,200 | Trimmed |
| 18 | UBS Group AG | $3.5M | 353,545 | Added |
| 19 | MILLENNIUM MANAGEMENT LLC | $3.3M | 341,676 | Trimmed |
| 20 | STATE STREET CORP | $3.2M | 325,991 | Added |
| 21 | Affinity Asset Advisors, LLC | $3.1M | 312,500 | Trimmed |
| 22 | Brevan Howard Capital Management LP | $3.0M | 309,817 | Added |
| 23 | Boxer Capital Management, LLC | $3.0M | 302,536 | Hold |
| 24 | Davidson Kempner Capital Management LP | $2.9M | 300,000 | Hold |
| 25 | ACADIAN ASSET MANAGEMENT LLC | $2.9M | 298,997 | Added |