| 1 | Lynx1 Capital Management LP | $20.3M | 1.5M | Hold |
| 2 | NEA Management Company, LLC | $17.1M | 1.3M | Hold |
| 3 | VR ADVISER, LLC | $13.3M | 1.0M | Hold |
| 4 | Atlas Venture Life Science Advisors, LLC | $12.7M | 962,884 | Trimmed |
| 5 | Balyasny Asset Management L.P. | $12.5M | 951,783 | Trimmed |
| 6 | BlackRock, Inc. | $10.8M | 817,621 | Added |
| 7 | VANGUARD GROUP INC | $10.0M | 755,159 | Added |
| 8 | Affinity Asset Advisors, LLC | $9.3M | 706,904 | Hold |
| 9 | Nantahala Capital Management, LLC | $8.7M | 660,036 | Hold |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $7.1M | 540,968 | Added |
| 11 | ADAR1 Capital Management, LLC | $7.1M | 540,054 | Hold |
| 12 | Driehaus Capital Management LLC | $5.9M | 450,045 | Hold |
| 13 | TCG Crossover Management, LLC | $5.5M | 416,301 | Hold |
| 14 | Kalehua Capital Management LLC | $5.3M | 405,040 | Added |
| 15 | Siren, L.L.C. | $4.6M | 347,718 | Hold |
| 16 | AQR CAPITAL MANAGEMENT LLC | $3.9M | 298,974 | Added |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | $3.9M | 296,870 | Added |
| 18 | 72 Investment Holdings, LLC | $3.6M | 276,831 | Hold |
| 19 | STATE STREET CORP | $3.1M | 232,587 | Added |
| 20 | TWO SIGMA INVESTMENTS, LP | $2.3M | 178,071 | Added |
| 21 | JPMORGAN CHASE & CO | $1.6M | 124,726 | Added |
| 22 | CITADEL ADVISORS LLC | $1.6M | 123,790 | Trimmed |
| 23 | MILLENNIUM MANAGEMENT LLC | $1.6M | 118,434 | Added |
| 24 | GOLDMAN SACHS GROUP INC | $1.5M | 116,983 | Added |
| 25 | RENAISSANCE TECHNOLOGIES LLC | $1.5M | 110,524 | Trimmed |