| 1 | FMR LLC | $974.5M | 11.7M | Added |
| 2 | BAKER BROS. ADVISORS LP | $721.1M | 8.7M | Hold |
| 3 | Avoro Capital Advisors LLC | $622.6M | 7.5M | Hold |
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | $504.8M | 6.1M | Trimmed |
| 5 | BVF INC/IL | $458.3M | 5.5M | Hold |
| 6 | T. Rowe Price Investment Management, Inc. | $455.2M | 5.5M | Added |
| 7 | BlackRock, Inc. | $421.5M | 5.1M | Added |
| 8 | Atlas Venture Life Science Advisors, LLC | $381.3M | 4.6M | Trimmed |
| 9 | WELLINGTON MANAGEMENT GROUP LLP | $324.0M | 3.9M | Trimmed |
| 10 | Siren, L.L.C. | $265.4M | 3.2M | Trimmed |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | $239.9M | 2.9M | New |
| 12 | VANGUARD PORTFOLIO MANAGEMENT LLC | $239.4M | 2.9M | New |
| 13 | STATE STREET CORP | $199.0M | 2.4M | Added |
| 14 | Capital Research Global Investors | $139.4M | 1.7M | Added |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $137.1M | 1.6M | Added |
| 16 | Driehaus Capital Management LLC | $86.9M | 1.0M | Trimmed |
| 17 | UBS Group AG | $85.3M | 1.0M | Added |
| 18 | GOLDMAN SACHS GROUP INC | $74.0M | 888,409 | Added |
| 19 | UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | $73.0M | 875,872 | Trimmed |
| 20 | Holocene Advisors, LP | $69.7M | 836,759 | Added |
| 21 | ALLIANCEBERNSTEIN L.P. | $69.1M | 888,035 | Trimmed |
| 22 | Merck & Co., Inc. | $64.3M | 772,165 | Hold |
| 23 | FRONTIER CAPITAL MANAGEMENT CO LLC | $63.3M | 759,848 | Added |
| 24 | Commodore Capital LP | $62.5M | 750,000 | Hold |
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | $52.2M | 626,925 | Added |