| 1 | Frazier Life Sciences Management, L.P. | $899.1M | 7.7M | Hold |
| 2 | Jupiter Topco LLC | $691.7M | 5.9M | New |
| 3 | VANGUARD GROUP INC | $590.0M | 5.0M | Added |
| 4 | BlackRock, Inc. | $513.9M | 4.4M | Trimmed |
| 5 | FMR LLC | $442.3M | 3.7M | Trimmed |
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | $310.9M | 2.7M | Added |
| 7 | STATE STREET CORP | $254.1M | 2.2M | Added |
| 8 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $164.5M | 1.4M | Added |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | $163.2M | 1.4M | Added |
| 10 | Invesco Ltd. | $159.7M | 1.4M | Trimmed |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | $153.4M | 1.3M | Trimmed |
| 12 | EVENTIDE ASSET MANAGEMENT, LLC | $146.2M | 1.2M | Trimmed |
| 13 | TANG CAPITAL MANAGEMENT LLC | $144.7M | 1.2M | Hold |
| 14 | Capital World Investors | $135.0M | 1.2M | Added |
| 15 | FRANKLIN RESOURCES INC | $135.0M | 1.2M | Trimmed |
| 16 | NOVO HOLDINGS A/S | $131.7M | 1.1M | Trimmed |
| 17 | TCG Crossover Management, LLC | $124.3M | 1.1M | Hold |
| 18 | BVF INC/IL | $123.6M | 1.1M | Trimmed |
| 19 | Polar Capital Holdings Plc | $99.0M | 845,524 | Added |
| 20 | Rock Springs Capital Management LP | $93.4M | 798,145 | Trimmed |
| 21 | TENOR CAPITAL MANAGEMENT Co., L.P. | $91.7M | 0 | Trimmed |
| 22 | BNP PARIBAS FINANCIAL MARKETS | $90.8M | 606,427 | Trimmed |
| 23 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $88.0M | 752,044 | Added |
| 24 | AMERIPRISE FINANCIAL INC | $85.1M | 726,694 | Added |
| 25 | TWO SIGMA INVESTMENTS, LP | $80.8M | 690,318 | Trimmed |