| 1 | JANUS HENDERSON GROUP PLC | $72.1M | 1.3M | Hold |
| 2 | RA CAPITAL MANAGEMENT, L.P. | $36.6M | 667,207 | Hold |
| 3 | Saturn V Capital Management LP | $18.9M | 345,626 | Added |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | $17.7M | 323,745 | Added |
| 5 | BlackRock, Inc. | $17.3M | 316,567 | Added |
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $16.9M | 309,195 | Trimmed |
| 7 | Siren, L.L.C. | $14.8M | 270,118 | Added |
| 8 | ADAR1 Capital Management, LLC | $14.5M | 264,278 | Added |
| 9 | Polar Capital Holdings Plc | $12.4M | 226,526 | Added |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | $12.0M | 218,463 | New |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | $9.6M | 174,342 | Trimmed |
| 12 | Sio Capital Management, LLC | $9.5M | 173,506 | New |
| 13 | Balyasny Asset Management L.P. | $7.5M | 136,443 | Added |
| 14 | TCG Crossover Management, LLC | $7.2M | 132,103 | Trimmed |
| 15 | Alyeska Investment Group, L.P. | $5.5M | 100,000 | Added |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | $5.5M | 99,918 | Added |
| 17 | Vivo Capital, LLC | $5.0M | 90,500 | Hold |
| 18 | STATE STREET CORP | $4.8M | 88,355 | Added |
| 19 | Bank of New York Mellon Corp | $4.3M | 78,618 | Added |
| 20 | Vestal Point Capital, LP | $3.6M | 65,418 | New |
| 21 | Walleye Capital LLC | $3.5M | 63,119 | New |
| 22 | BANK OF AMERICA CORP /DE/ | $3.3M | 59,699 | Added |
| 23 | CITADEL ADVISORS LLC | $3.2M | 58,436 | Added |
| 24 | MILLENNIUM MANAGEMENT LLC | $2.9M | 52,951 | Trimmed |
| 25 | PRICE T ROWE ASSOCIATES INC /MD/ | $2.6M | 47,702 | Added |