| 1 | FRANKLIN RESOURCES INC | $5.3M | 938,666 | New |
| 2 | Avidity Partners Management LP | $5.3M | 775,538 | New |
| 3 | Siren, L.L.C. | $5.0M | 892,074 | New |
| 4 | Vivo Capital, LLC | $4.6M | 813,666 | New |
| 5 | Point72 Asset Management, L.P. | $3.9M | 690,778 | New |
| 6 | Woodline Partners LP | $2.8M | 500,432 | New |
| 7 | SPHERA FUNDS MANAGEMENT LTD. | $2.8M | 489,207 | New |
| 8 | SUVRETTA CAPITAL MANAGEMENT, LLC | $2.7M | 475,000 | New |
| 9 | Soleus Capital Management, L.P. | $2.3M | 414,359 | New |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.1M | 380,354 | New |
| 11 | Saturn V Capital Management LP | $2.0M | 350,000 | New |
| 12 | MILLENNIUM MANAGEMENT LLC | $1.7M | 298,433 | New |
| 13 | 683 Capital Management, LLC | $1.3M | 230,833 | New |
| 14 | Empery Asset Management, LP | $1.3M | 230,100 | New |
| 15 | ADAR1 Capital Management, LLC | $1.3M | 222,555 | New |
| 16 | AWM Investment Company, Inc. | $1.2M | 215,000 | New |
| 17 | Stonepine Capital Management, LLC | $563,000 | 100,000 | New |
| 18 | CITADEL ADVISORS LLC | $239,230 | 42,492 | New |
| 19 | HRT FINANCIAL LP | $171,000 | 30,461 | New |
| 20 | MORGAN STANLEY | $119,260 | 21,183 | New |
| 21 | JANE STREET GROUP, LLC | $110,399 | 19,608 | New |
| 22 | Royal Bank of Canada | $91,000 | 16,245 | New |
| 23 | Monashee Investment Management LLC | $67,560 | 12,000 | New |
| 24 | GEODE CAPITAL MANAGEMENT, LLC | $67,036 | 11,907 | New |
| 25 | Propel Bio Management, LLC | $57,116 | 10,145 | New |