| 1 | FRANKLIN RESOURCES INC | $7.2M | 938,666 | Hold |
| 2 | Siren, L.L.C. | $6.9M | 892,074 | Hold |
| 3 | Vivo Capital, LLC | $6.3M | 813,666 | Hold |
| 4 | Point72 Asset Management, L.P. | $5.3M | 682,700 | Trimmed |
| 5 | SPHERA FUNDS MANAGEMENT LTD. | $5.1M | 652,590 | Added |
| 6 | Woodline Partners LP | $3.9M | 500,432 | Hold |
| 7 | Stonepine Capital Management, LLC | $3.7M | 491,624 | Added |
| 8 | SUVRETTA CAPITAL MANAGEMENT, LLC | $3.7M | 475,000 | Hold |
| 9 | Avidity Partners Management LP | $3.0M | 387,769 | Hold |
| 10 | Saturn V Capital Management LP | $2.7M | 350,000 | Hold |
| 11 | Soleus Capital Management, L.P. | $2.4M | 314,359 | Trimmed |
| 12 | 683 Capital Management, LLC | $1.8M | 230,833 | Hold |
| 13 | ADAR1 Capital Management, LLC | $1.7M | 222,555 | Hold |
| 14 | AWM Investment Company, Inc. | $1.4M | 180,000 | New |
| 15 | MILLENNIUM MANAGEMENT LLC | $1.2M | 152,768 | Trimmed |
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $1.2M | 150,000 | Trimmed |
| 17 | Empery Asset Management, LP | $832,703 | 107,100 | Trimmed |
| 18 | CITADEL ADVISORS LLC | $526,663 | 67,738 | Added |
| 19 | MORGAN STANLEY | $200,066 | 25,732 | Added |
| 20 | China Universal Asset Management Co., Ltd. | $155,500 | 20,000 | Added |
| 21 | Royal Bank of Canada | $124,000 | 15,863 | Trimmed |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | $92,576 | 11,907 | Hold |
| 23 | UBS Group AG | $6,073 | 781 | Added |
| 24 | JPMORGAN CHASE & CO | $2,485 | 315 | New |
| 25 | Federation des caisses Desjardins du Quebec | $143 | 19 | Hold |