| 1 | ARK Investment Management LLC | $285.5M | 16.9M | Added |
| 2 | BlackRock, Inc. | $260.7M | 15.4M | Added |
| 3 | VANGUARD GROUP INC | $244.6M | 14.5M | Added |
| 4 | STATE STREET CORP | $156.3M | 9.2M | Added |
| 5 | D. E. Shaw & Co., Inc. | $109.0M | 6.4M | Added |
| 6 | TWO SIGMA INVESTMENTS, LP | $88.6M | 5.2M | Added |
| 7 | FMR LLC | $80.8M | 4.8M | Added |
| 8 | RA CAPITAL MANAGEMENT, L.P. | $76.6M | 4.5M | New |
| 9 | REGENERON PHARMACEUTICALS, INC. | $62.7M | 3.7M | Hold |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | $61.4M | 3.6M | Added |
| 11 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $55.5M | 3.3M | Added |
| 12 | Amova Asset Management Americas, Inc. | $49.0M | 2.9M | Added |
| 13 | Sumitomo Mitsui Trust Group, Inc. | $49.0M | 2.9M | Added |
| 14 | DIMENSIONAL FUND ADVISORS LP | $44.0M | 2.6M | Added |
| 15 | UBS Group AG | $41.4M | 2.4M | Trimmed |
| 16 | GOLDMAN SACHS GROUP INC | $38.3M | 2.3M | Added |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $36.5M | 2.2M | Trimmed |
| 18 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | $35.0M | 2.1M | Added |
| 19 | Contrarius Group Holdings Ltd | $33.1M | 2.0M | Added |
| 20 | JUPITER ASSET MANAGEMENT LTD | $31.3M | 1.8M | Added |
| 21 | MORGAN STANLEY | $29.3M | 1.7M | Trimmed |
| 22 | ARMISTICE CAPITAL, LLC | $25.4M | 1.5M | Added |
| 23 | RENAISSANCE TECHNOLOGIES LLC | $23.7M | 1.4M | New |
| 24 | NORTHERN TRUST CORP | $21.5M | 1.3M | Added |
| 25 | HRT FINANCIAL LP | $21.0M | 1.2M | Added |