81 institutions reported holding $98.1M of ORCHESTRA BIOMED HLDGS INC COM (OBIO) in SEC 13F filings for 2026-03-31. Largest institutional holders: RTW INVESTMENTS, LP ($35.3M), PERCEPTIVE ADVISORS LLC ($21.4M), VANGUARD CAPITAL MANAGEMENT LLC ($9.4M), Alyeska Investment Group, L.P. ($4.2M), Propel Bio Management, LLC ($3.8M). Source: SEC Form 13F.
| Rank | Institution | Value | Shares | Change |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | $35.3M | 8.3M | Hold |
| 2 | PERCEPTIVE ADVISORS LLC | $21.4M | 5.0M | Trimmed |
| 3 | VANGUARD CAPITAL MANAGEMENT LLC | $9.4M | 2.2M | New |
| 4 | Alyeska Investment Group, L.P. | $4.2M | 1.0M | Hold |
| 5 | Propel Bio Management, LLC | $3.8M | 896,701 | New |
| 6 | MILLENNIUM MANAGEMENT LLC | $3.0M | 702,543 | Added |
| 7 | BlackRock, Inc. | $2.7M | 635,714 | Added |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | $2.1M | 485,492 | Added |
| 9 | Affinity Asset Advisors, LLC | $1.7M | 402,550 | Trimmed |
| 10 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1.1M | 265,499 | Added |
| 11 | Knott David M Jr | $1.1M | 253,651 | Added |
| 12 | VANGUARD FIDUCIARY TRUST CO | $999,660 | 235,214 | New |
| 13 | Simplify Asset Management Inc. | $932,395 | 219,387 | New |
| 14 | MARSHALL WACE, LLP | $801,059 | 188,484 | Added |
| 15 | 683 Capital Management, LLC | $786,250 | 185,000 | Trimmed |
| 16 | STATE STREET CORP | $719,993 | 169,410 | Added |
| 17 | GOLDMAN SACHS GROUP INC | $659,779 | 155,242 | Added |
| 18 | DAFNA Capital Management LLC | $539,074 | 126,841 | Hold |
| 19 | NORTHERN TRUST CORP | $502,665 | 118,274 | Added |
| 20 | Qube Research & Technologies Ltd | $463,050 | 108,953 | Added |
| 21 | IFP Advisors, Inc | $420,270 | 98,887 | Added |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $414,464 | 97,521 | Trimmed |
| 23 | Point72 Asset Management, L.P. | $373,524 | 87,888 | Trimmed |
| 24 | CITADEL ADVISORS LLC | $336,536 | 79,185 | Added |
| 25 | Hudson Bay Capital Management LP | $302,320 | 71,134 | Added |
Source: SEC Form 13F filings · as of 2026-03-31