| 1 | RA CAPITAL MANAGEMENT, L.P. | $16.6M | 4.0M | New |
| 2 | ACORN CAPITAL ADVISORS, LLC | $11.8M | 2.8M | Hold |
| 3 | StepStone Group LP | $11.0M | 2.7M | Added |
| 4 | ADAR1 Capital Management, LLC | $10.1M | 2.4M | Added |
| 5 | Prosight Management, LP | $8.9M | 2.2M | Added |
| 6 | BVF INC/IL | $8.2M | 2.0M | New |
| 7 | Vivo Capital, LLC | $8.0M | 1.9M | New |
| 8 | Vestal Point Capital, LP | $7.6M | 1.8M | Added |
| 9 | Foresite Capital Management VI LLC | $6.0M | 1.4M | New |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $5.0M | 1.2M | New |
| 11 | Sio Capital Management, LLC | $4.5M | 1.1M | New |
| 12 | VANGUARD CAPITAL MANAGEMENT LLC | $2.4M | 582,477 | New |
| 13 | NEA Management Company, LLC | $2.0M | 478,548 | Hold |
| 14 | Rosalind Advisors, Inc. | $1.8M | 443,763 | Trimmed |
| 15 | RENAISSANCE TECHNOLOGIES LLC | $1.6M | 377,250 | Added |
| 16 | Carlyle Group Inc. | $1.1M | 269,895 | Hold |
| 17 | Affinity Asset Advisors, LLC | $997,587 | 240,963 | New |
| 18 | Sofinnova Investments, Inc. | $586,638 | 141,700 | New |
| 19 | Stonepine Capital Management, LLC | $548,873 | 132,578 | New |
| 20 | Shay Capital LLC | $547,387 | 132,219 | Trimmed |
| 21 | CANTOR FITZGERALD, L. P. | $413,586 | 99,900 | Trimmed |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | $408,845 | 98,750 | Added |
| 23 | Rangeley Capital, LLC | $393,300 | 95,000 | Trimmed |
| 24 | Aisling Capital Management LP | $366,833 | 88,607 | Hold |
| 25 | BlackRock, Inc. | $205,290 | 49,587 | Trimmed |