| 1 | FMR LLC | $227.0M | 6.6M | Added |
| 2 | GENERAL ATLANTIC, L.P. | $226.5M | 6.6M | Trimmed |
| 3 | Foresite Capital Management IV, LLC | $165.2M | 4.8M | Hold |
| 4 | venBio Partners LLC | $160.6M | 4.6M | Added |
| 5 | VIKING GLOBAL INVESTORS LP | $126.3M | 3.7M | Hold |
| 6 | EQT Fund Management S.a r.l. | $118.4M | 3.4M | Hold |
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | $116.7M | 3.4M | Added |
| 8 | Bain Capital Life Sciences Investors, LLC | $92.5M | 2.7M | Hold |
| 9 | WELLINGTON MANAGEMENT GROUP LLP | $82.7M | 2.4M | Added |
| 10 | Polar Capital Holdings Plc | $80.4M | 2.3M | Added |
| 11 | Point72 Asset Management, L.P. | $56.8M | 1.6M | Added |
| 12 | Commodore Capital LP | $49.3M | 1.4M | Trimmed |
| 13 | NOVO HOLDINGS A/S | $48.4M | 1.4M | Trimmed |
| 14 | Saturn V Capital Management LP | $45.4M | 1.3M | Added |
| 15 | TCG Crossover Management, LLC | $34.9M | 1.0M | New |
| 16 | Sofinnova Investments, Inc. | $30.5M | 881,299 | Added |
| 17 | 5AM Venture Management, LLC | $27.6M | 797,600 | Hold |
| 18 | Seven Fleet Capital Management LP | $26.8M | 774,501 | Added |
| 19 | BlackRock, Inc. | $26.7M | 771,454 | Added |
| 20 | Cormorant Asset Management, LP | $25.9M | 750,000 | Trimmed |
| 21 | Soleus Capital Management, L.P. | $25.3M | 730,907 | Added |
| 22 | Jones Hill Capital LP | $23.4M | 677,879 | Added |
| 23 | Patient Square Capital LP | $23.2M | 671,209 | Added |
| 24 | Foresite Capital Management V, LLC | $23.0M | 664,142 | Added |
| 25 | Kynam Capital Management, LP | $22.9M | 661,795 | Added |