| 1 | GREAT POINT PARTNERS LLC | $3.8M | 944,292 | Trimmed |
| 2 | Squadron Capital Management LLC | $3.1M | 756,884 | Trimmed |
| 3 | Propel Bio Management, LLC | $2.2M | 543,478 | New |
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.2M | 543,478 | New |
| 5 | Woodline Partners LP | $1.6M | 387,520 | New |
| 6 | VANGUARD GROUP INC | $1.4M | 355,653 | Trimmed |
| 7 | Avidity Partners Management LP | $1.1M | 260,206 | Trimmed |
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | $1.0M | 247,811 | Trimmed |
| 9 | MILLENNIUM MANAGEMENT LLC | $735,807 | 180,788 | Trimmed |
| 10 | HEIGHTS CAPITAL MANAGEMENT, INC | $612,743 | 150,551 | Trimmed |
| 11 | DAFNA Capital Management LLC | $552,983 | 135,868 | Trimmed |
| 12 | Empery Asset Management, LP | $514,656 | 126,451 | Trimmed |
| 13 | ACADIAN ASSET MANAGEMENT LLC | $473,000 | 116,669 | Trimmed |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | $334,169 | 82,093 | Trimmed |
| 15 | RENAISSANCE TECHNOLOGIES LLC | $311,457 | 76,525 | Trimmed |
| 16 | ADAR1 Capital Management, LLC | $201,005 | 49,387 | New |
| 17 | BlackRock, Inc. | $168,995 | 41,522 | Trimmed |
| 18 | Velan Capital Investment Management LP | $162,800 | 40,000 | New |
| 19 | NORTHERN TRUST CORP | $91,107 | 22,385 | Trimmed |
| 20 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | $63,305 | 15,554 | Trimmed |
| 21 | Empowered Funds, LLC | $62,931 | 15,462 | Trimmed |
| 22 | WEALTH EFFECTS LLC | $56,467 | 13,874 | Trimmed |
| 23 | XTX Topco Ltd | $52,743 | 12,959 | Trimmed |
| 24 | UBS Group AG | $45,678 | 11,223 | Added |
| 25 | DIMENSIONAL FUND ADVISORS LP | $40,781 | 10,020 | New |