| 1 | JANUS HENDERSON GROUP PLC | $237.6M | 7.1M | Trimmed |
| 2 | FMR LLC | $193.8M | 5.8M | Trimmed |
| 3 | WELLINGTON MANAGEMENT GROUP LLP | $148.2M | 4.4M | Added |
| 4 | BlackRock, Inc. | $125.3M | 3.7M | Trimmed |
| 5 | STATE STREET CORP | $89.8M | 2.7M | Added |
| 6 | Nantahala Capital Management, LLC | $83.5M | 2.5M | Added |
| 7 | Avoro Capital Advisors LLC | $77.0M | 2.3M | Trimmed |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | $72.1M | 2.2M | New |
| 9 | Polar Capital Holdings Plc | $56.9M | 1.7M | Added |
| 10 | Caption Management, LLC | $53.2M | 1.6M | Added |
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $52.5M | 1.6M | Added |
| 12 | Khrom Capital Management LLC | $50.6M | 1.5M | New |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | $41.4M | 1.2M | Added |
| 14 | Woodline Partners LP | $37.2M | 1.1M | Added |
| 15 | Deep Track Capital, LP | $36.1M | 1.1M | Added |
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | $34.4M | 1.0M | Trimmed |
| 17 | BRAIDWELL LP | $32.1M | 959,259 | Trimmed |
| 18 | READYSTATE ASSET MANAGEMENT LP | $31.9M | 952,165 | Added |
| 19 | FRANKLIN RESOURCES INC | $28.0M | 835,178 | Added |
| 20 | Vestal Point Capital, LP | $24.4M | 730,000 | New |
| 21 | Commodore Capital LP | $21.8M | 652,432 | Trimmed |
| 22 | MILLENNIUM MANAGEMENT LLC | $21.0M | 626,513 | Trimmed |
| 23 | Hood River Capital Management LLC | $20.9M | 623,421 | Added |
| 24 | Pictet Asset Management Holding SA | $20.6M | 616,217 | Trimmed |
| 25 | SCHRODER INVESTMENT MANAGEMENT GROUP | $19.8M | 648,827 | Added |