| 1 | SUVRETTA CAPITAL MANAGEMENT, LLC | $50.5M | 2.0M | Added |
| 2 | Avoro Capital Advisors LLC | $36.1M | 1.4M | New |
| 3 | BAKER BROS. ADVISORS LP | $32.2M | 1.3M | New |
| 4 | Balyasny Asset Management L.P. | $26.1M | 1.0M | Added |
| 5 | Logos Global Management LP | $18.1M | 722,020 | Added |
| 6 | RA CAPITAL MANAGEMENT, L.P. | $18.1M | 722,020 | New |
| 7 | Fairmount Funds Management LLC | $18.1M | 722,020 | New |
| 8 | Vivo Capital, LLC | $18.1M | 722,020 | Hold |
| 9 | Caligan Partners LP | $15.7M | 629,467 | Added |
| 10 | B Group, Inc. | $15.3M | 610,169 | New |
| 11 | Trails Edge Capital Partners, LP | $12.9M | 515,335 | Added |
| 12 | FRANKLIN RESOURCES INC | $12.4M | 494,516 | Added |
| 13 | ADAR1 Capital Management, LLC | $9.0M | 361,010 | New |
| 14 | Octagon Capital Advisors LP | $9.0M | 361,010 | New |
| 15 | Cormorant Asset Management, LP | $7.7M | 1.0M | Added |
| 16 | MARSHALL WACE, LLP | $5.2M | 206,508 | Added |
| 17 | Boxer Capital Management, LLC | $4.5M | 180,505 | New |
| 18 | Patient Square Capital LP | $4.4M | 175,050 | New |
| 19 | Alyeska Investment Group, L.P. | $3.6M | 144,404 | New |
| 20 | Affinity Asset Advisors, LLC | $3.6M | 144,404 | New |
| 21 | BOOTHBAY FUND MANAGEMENT, LLC | $3.3M | 133,643 | Added |
| 22 | AWM Investment Company, Inc. | $2.8M | 111,343 | New |
| 23 | Richmond Investment Services, LLC | $2.0M | 79,731 | New |
| 24 | Ikarian Capital, LLC | $884,650 | 35,386 | Added |
| 25 | UBS Group AG | $538,525 | 21,541 | Added |