41 institutions reported holding $48.8M of SPRUCE BIOSCIENCES INC (SPRB) in SEC 13F filings for 2026-03-31. Largest institutional holders: Ikarian Capital, LLC ($7.9M), MILLENNIUM MANAGEMENT LLC ($7.3M), CITADEL ADVISORS LLC ($4.6M), ADAR1 Capital Management, LLC ($3.8M), Alyeska Investment Group, L.P. ($3.4M). Source: SEC Form 13F.
| Rank | Institution | Value | Shares | Change |
|---|---|---|---|---|
| 1 | Ikarian Capital, LLC | $7.9M | 121,356 | Hold |
| 2 | MILLENNIUM MANAGEMENT LLC | $7.3M | 111,888 | New |
| 3 | CITADEL ADVISORS LLC | $4.6M | 69,999 | Hold |
| 4 | ADAR1 Capital Management, LLC | $3.8M | 58,600 | Added |
| 5 | Alyeska Investment Group, L.P. | $3.4M | 51,671 | Hold |
| 6 | WELLINGTON MANAGEMENT GROUP LLP | $3.2M | 48,796 | Trimmed |
| 7 | BOOTHBAY FUND MANAGEMENT, LLC | $2.7M | 42,080 | Trimmed |
| 8 | Balyasny Asset Management L.P. | $2.6M | 40,000 | Hold |
| 9 | Carlyle Group Inc. | $2.5M | 38,620 | Hold |
| 10 | Quinn Opportunity Partners LLC | $1.8M | 26,810 | Added |
| 11 | ExodusPoint Capital Management, LP | $1.4M | 22,000 | Trimmed |
| 12 | VANGUARD CAPITAL MANAGEMENT LLC | $1.2M | 18,337 | New |
| 13 | BlackRock, Inc. | $1.1M | 16,938 | Hold |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | $842,729 | 12,889 | Added |
| 15 | STEMPOINT CAPITAL LP | $831,252 | 12,720 | New |
| 16 | Squadron Capital Management LLC | $797,270 | 12,200 | Trimmed |
| 17 | DIADEMA PARTNERS LP | $653,500 | 10,000 | New |
| 18 | VANGUARD FIDUCIARY TRUST CO | $360,340 | 5,514 | New |
| 19 | GOLDMAN SACHS GROUP INC | $359,817 | 5,506 | New |
| 20 | STATE STREET CORP | $352,890 | 5,400 | Trimmed |
| 21 | Resolute Capital Asset Partners LLC | $261,400 | 4,000 | Hold |
| 22 | UBS Group AG | $256,107 | 3,919 | Trimmed |
| 23 | Persistent Asset Partners Ltd | $165,205 | 2,528 | New |
| 24 | MORGAN STANLEY | $92,471 | 1,415 | Added |
| 25 | Lion Point Capital, LP | $65,350 | 1,000 | Hold |
Source: SEC Form 13F filings · as of 2026-03-31