| 1 | RA CAPITAL MANAGEMENT, L.P. | $63.5M | 9.9M | Hold |
| 2 | 5AM Venture Management, LLC | $15.2M | 2.4M | Hold |
| 3 | VR ADVISER, LLC | $10.4M | 1.6M | Hold |
| 4 | venBio Partners LLC | $3.4M | 531,337 | Trimmed |
| 5 | FRANKLIN RESOURCES INC | $3.4M | 520,327 | Hold |
| 6 | Revelation Capital Management, LLC | $1.9M | 299,311 | Hold |
| 7 | BlackRock, Inc. | $1.4M | 213,388 | Added |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | $1.3M | 207,686 | New |
| 9 | WELLINGTON MANAGEMENT GROUP LLP | $1.3M | 194,108 | Hold |
| 10 | Propel Bio Management, LLC | $949,818 | 146,369 | New |
| 11 | MILLENNIUM MANAGEMENT LLC | $793,859 | 123,270 | Trimmed |
| 12 | TWO SIGMA INVESTMENTS, LP | $740,864 | 115,041 | Trimmed |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | $655,451 | 101,695 | Added |
| 14 | Alyeska Investment Group, L.P. | $644,000 | 100,000 | Hold |
| 15 | RENAISSANCE TECHNOLOGIES LLC | $515,445 | 80,038 | Trimmed |
| 16 | JANE STREET GROUP, LLC | $254,354 | 39,496 | Trimmed |
| 17 | STATE STREET CORP | $230,707 | 35,824 | Hold |
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | $225,400 | 35,000 | Hold |
| 19 | VANGUARD FIDUCIARY TRUST CO | $211,296 | 32,810 | New |
| 20 | PANAGORA ASSET MANAGEMENT INC | $197,721 | 30,702 | New |
| 21 | Velan Capital Investment Management LP | $161,000 | 25,000 | New |
| 22 | Simplify Asset Management Inc. | $149,601 | 23,230 | New |
| 23 | Sanctuary Advisors, LLC | $138,982 | 21,581 | New |
| 24 | BAILARD, INC. | $133,308 | 20,700 | New |
| 25 | DIMENSIONAL FUND ADVISORS LP | $131,183 | 20,370 | New |