Every 13F-reported equity position this quarter, with its quarter-over-quarter change — each row traces back to the SEC filing.

5AM Venture Management, LLC 13F Holdings -- Portfolio & Top Positions (2026-06-30)

Name: 5AM Venture Management, LLC 13F Holdings (2026-06-30)
Creator: ko.io

5AM Venture Management, LLC (CIK 1799883) reported $287.9M across 16 reported positions in its SEC 13F filing for 2026-06-30. Largest positions: MPLT ($34.0M, 11.83%), TYRA ($32.9M, 11.42%), TRDA ($29.9M, 10.37%), PHVS ($27.6M, 9.58%), CAMP ($25.6M, 8.91%). Source: SEC Form 13F.

Rank	Ticker	Company	Value	% Portfolio	Shares	Action
1	MPLT	MAPLIGHT THERAPEUTICS INC	$34.0M	11.83%	950,011	Hold
2	TYRA	TYRA BIOSCIENCES INC	$32.9M	11.42%	1.0M	Hold
3	TRDA	ENTRADA THERAPEUTICS INC	$29.9M	10.37%	4.1M	Hold
4	PHVS	PHARVARIS N V	$27.6M	9.58%	797,600	Hold
5	CAMP	CAMP4 THERAPEUTICS CORP	$25.6M	8.91%	5.9M	Hold
6	ARTV	ARTIVA BIOTHERAPEUTICS INC	$22.8M	7.93%	2.4M	Hold
7	TECX	TECTONIC THERAPEUTIC INC	$20.9M	7.24%	606,660	Hold
8	ZNTL	ZENTALIS PHARMACEUTICALS INC	$19.1M	6.65%	3.9M	Hold
9	CLDX	CELLDEX THERAPEUTICS INC NEW	$18.5M	6.43%	497,270	Hold
10	EYPT	EYEPOINT INC	$15.0M	5.22%	1.1M	Hold
11	BHVN	BIOHAVEN LTD	$11.0M	3.82%	738,972	Hold
12	SRZN	SURROZEN INC	$7.0M	2.44%	271,250	Trimmed
13	SKYE	SKYE BIOSCIENCE INC	$6.7M	2.33%	9.7M	Hold
14	ALXO	ALX ONCOLOGY HLDGS INC	$6.3M	2.20%	3.1M	Hold
15	TARA	PROTARA THERAPEUTICS INC	$5.2M	1.82%	1.4M	Hold
16	SLN	SILENCE THERAPEUTICS PLC	$5.2M	1.82%	476,200	Hold
17	CNTA	CENTESSA PHARMACEUTICALS PLC	$0	0.00%	0	Exited
18	ERAS	ERASCA INC	$0	0.00%	0	Exited
19	RLYB	RALLYBIO CORP	$0	0.00%	0	Exited
20	GHRS	GH RESEARCH PLC	$0	0.00%	0	Exited

Source: SEC Form 13F filings · as of 2026-06-30