5AM Venture Management, LLC 13F Holdings · Q2 2026
5AM Venture Management, LLC reported 16 securities worth $287.89M in its SEC 13F filing for Q2 2026 (period ended 2026-06-30). Top holdings: MPLT (11.83%), TYRA (11.42%), TRDA (10.37%). Among its top 25 positions this quarter: 1 trimmed, 4 exited.
| Rank | Ticker | Company | Value | % Portfolio | Shares | Action |
|---|---|---|---|---|---|---|
| 1 | MPLT | MAPLIGHT THERAPEUTICS INC | $34.0M | 11.83% | 950,011 | Hold |
| 2 | TYRA | TYRA BIOSCIENCES INC | $32.9M | 11.42% | 1.0M | Hold |
| 3 | TRDA | ENTRADA THERAPEUTICS INC | $29.9M | 10.37% | 4.1M | Hold |
| 4 | PHVS | PHARVARIS N V | $27.6M | 9.58% | 797,600 | Hold |
| 5 | CAMP | CAMP4 THERAPEUTICS CORP | $25.6M | 8.91% | 5.9M | Hold |
| 6 | ARTV | ARTIVA BIOTHERAPEUTICS INC | $22.8M | 7.93% | 2.4M | Hold |
| 7 | TECX | TECTONIC THERAPEUTIC INC | $20.9M | 7.24% | 606,660 | Hold |
| 8 | ZNTL | ZENTALIS PHARMACEUTICALS INC | $19.1M | 6.65% | 3.9M | Hold |
| 9 | CLDX | CELLDEX THERAPEUTICS INC NEW | $18.5M | 6.43% | 497,270 | Hold |
| 10 | EYPT | EYEPOINT INC | $15.0M | 5.22% | 1.1M | Hold |
| 11 | BHVN | BIOHAVEN LTD | $11.0M | 3.82% | 738,972 | Hold |
| 12 | SRZN | SURROZEN INC | $7.0M | 2.44% | 271,250 | Trimmed |
| 13 | SKYE | SKYE BIOSCIENCE INC | $6.7M | 2.33% | 9.7M | Hold |
| 14 | ALXO | ALX ONCOLOGY HLDGS INC | $6.3M | 2.20% | 3.1M | Hold |
| 15 | SLN | SILENCE THERAPEUTICS PLC | $5.2M | 1.82% | 476,200 | Hold |
| 16 | TARA | PROTARA THERAPEUTICS INC | $5.2M | 1.82% | 1.4M | Hold |
| 17 | CNTA | CENTESSA PHARMACEUTICALS PLC | $0 | 0.00% | 0 | Exited |
| 18 | ERAS | ERASCA INC | $0 | 0.00% | 0 | Exited |
| 19 | GHRS | GH RESEARCH PLC | $0 | 0.00% | 0 | Exited |
| 20 | RLYB | RALLYBIO CORP | $0 | 0.00% | 0 | Exited |
Source: SEC Form 13F filings · as of 2026-06-30
Every position in this 13F-HR, with its change from the prior quarter.
13F holdings, latest quarter
SourceSEC EDGAR13F-HR