| 1 | NOVO HOLDINGS A/S | $132.1M | 3.7M | Hold |
| 2 | FCPM III SERVICES B.V. | $115.6M | 3.2M | Hold |
| 3 | T. Rowe Price Investment Management, Inc. | $99.7M | 2.8M | Trimmed |
| 4 | GOLDMAN SACHS GROUP INC | $69.8M | 1.9M | Trimmed |
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | $51.0M | 1.4M | Added |
| 6 | BlackRock, Inc. | $36.7M | 1.0M | Trimmed |
| 7 | VANGUARD GROUP INC | $36.3M | 1.0M | Added |
| 8 | Nan Fung Group Holdings Ltd | $34.8M | 971,253 | Hold |
| 9 | 5AM Venture Management, LLC | $34.0M | 950,011 | Hold |
| 10 | Sanofi | $32.7M | 912,041 | Hold |
| 11 | STATE STREET CORP | $30.5M | 852,150 | Added |
| 12 | FMR LLC | $29.5M | 823,556 | Added |
| 13 | Blue Owl Capital Holdings LP | $26.2M | 729,929 | Trimmed |
| 14 | Paradigm Biocapital Advisors LP | $24.6M | 685,852 | New |
| 15 | Pivotal bioVenture Partners Investment Advisor LLC | $21.9M | 611,446 | Trimmed |
| 16 | Velan Capital Investment Management LP | $17.7M | 492,893 | Hold |
| 17 | Siren, L.L.C. | $16.1M | 450,000 | Hold |
| 18 | Capital World Investors | $14.9M | 415,730 | New |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | $14.4M | 402,051 | Trimmed |
| 20 | BAKER BROS. ADVISORS LP | $13.1M | 364,705 | Hold |
| 21 | DAFNA Capital Management LLC | $6.1M | 171,006 | Hold |
| 22 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $6.1M | 170,862 | Trimmed |
| 23 | Freestone Grove Partners LP | $6.1M | 168,912 | Trimmed |
| 24 | Sixth Street Partners Management Company, L.P. | $4.9M | 136,818 | New |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4.9M | 136,818 | Trimmed |