| 1 | Jupiter Topco LLC | $27.6M | 6.3M | New |
| 2 | 5AM Venture Management, LLC | $25.6M | 5.9M | Hold |
| 3 | FMR LLC | $21.4M | 4.9M | Trimmed |
| 4 | Vivo Capital, LLC | $18.6M | 4.2M | Hold |
| 5 | Balyasny Asset Management L.P. | $11.3M | 2.6M | Trimmed |
| 6 | a16z Capital Management, L.L.C. | $9.3M | 2.1M | Hold |
| 7 | VANGUARD GROUP INC | $8.7M | 2.0M | Added |
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $8.6M | 2.0M | Hold |
| 9 | Trails Edge Capital Partners, LP | $8.4M | 1.9M | Trimmed |
| 10 | BlackRock, Inc. | $7.2M | 1.6M | Added |
| 11 | ENAVATE SCIENCES GP, LLC | $6.2M | 1.4M | Trimmed |
| 12 | Stonepine Capital Management, LLC | $6.1M | 1.4M | Hold |
| 13 | HarbourVest Partners LLC | $5.6M | 1.3M | Hold |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | $3.5M | 795,651 | Added |
| 15 | SummitTX Capital, L.P. | $3.2M | 725,160 | Added |
| 16 | SILVERARC CAPITAL MANAGEMENT, LLC | $2.9M | 653,594 | Hold |
| 17 | STATE STREET CORP | $1.6M | 362,300 | Added |
| 18 | NORTHERN TRUST CORP | $1.1M | 248,673 | Added |
| 19 | GOLDMAN SACHS GROUP INC | $1.1M | 241,393 | Added |
| 20 | Birchview Capital, LP | $524,400 | 120,000 | New |
| 21 | TWO SIGMA INVESTMENTS, LP | $457,146 | 104,610 | Trimmed |
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $422,404 | 96,660 | Added |
| 23 | Sixth Street Partners Management Company, L.P. | $422,404 | 96,660 | New |
| 24 | Bank of New York Mellon Corp | $364,550 | 83,421 | Added |
| 25 | VICTORY CAPITAL MANAGEMENT INC | $360,307 | 82,450 | Hold |