| 1 | Caligan Partners LP | $27.6M | 6.1M | New |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $27.4M | 6.0M | Added |
| 3 | BIOS Capital Management, LP | $16.8M | 3.7M | Hold |
| 4 | Balyasny Asset Management L.P. | $12.4M | 2.7M | Hold |
| 5 | MILLENNIUM MANAGEMENT LLC | $12.0M | 2.6M | Added |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | $11.1M | 2.4M | New |
| 7 | MARSHALL WACE, LLP | $10.5M | 2.3M | Added |
| 8 | Boxer Capital Management, LLC | $10.2M | 2.2M | New |
| 9 | ADAR1 Capital Management, LLC | $8.4M | 1.8M | Added |
| 10 | PERCEPTIVE ADVISORS LLC | $8.4M | 1.8M | Trimmed |
| 11 | Nantahala Capital Management, LLC | $7.7M | 1.7M | Trimmed |
| 12 | Woodline Partners LP | $6.2M | 1.4M | New |
| 13 | BOOTHBAY FUND MANAGEMENT, LLC | $5.4M | 1.2M | New |
| 14 | FARALLON CAPITAL MANAGEMENT LLC | $4.5M | 1.0M | New |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4.1M | 904,783 | Added |
| 16 | Bleichroeder LP | $3.4M | 736,842 | Hold |
| 17 | Mink Brook Asset Management LLC | $2.7M | 590,552 | Trimmed |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | $2.5M | 538,347 | Added |
| 19 | Trails Edge Capital Partners, LP | $2.3M | 500,000 | New |
| 20 | Opaleye Management Inc. | $2.3M | 1.1M | Hold |
| 21 | AMERIPRISE FINANCIAL INC | $1.8M | 388,491 | New |
| 22 | GOLDMAN SACHS GROUP INC | $1.5M | 326,809 | New |
| 23 | GREAT POINT PARTNERS LLC | $1.5M | 324,340 | New |
| 24 | VANGUARD FIDUCIARY TRUST CO | $1.3M | 281,801 | New |
| 25 | UBS Group AG | $1.2M | 257,649 | Added |