| 1 | FMR LLC | $202.8M | 9.1M | Added |
| 2 | Jupiter Topco LLC | $139.4M | 6.3M | New |
| 3 | Fairmount Funds Management LLC | $101.2M | 4.6M | Hold |
| 4 | RA CAPITAL MANAGEMENT, L.P. | $81.6M | 3.7M | Hold |
| 5 | VR ADVISER, LLC | $71.6M | 3.2M | Hold |
| 6 | VANGUARD GROUP INC | $68.7M | 3.1M | Added |
| 7 | Bellevue Group AG | $67.9M | 3.1M | Trimmed |
| 8 | Paradigm Biocapital Advisors LP | $63.5M | 2.9M | New |
| 9 | BlackRock, Inc. | $62.2M | 2.8M | Added |
| 10 | FRANKLIN RESOURCES INC | $62.0M | 2.8M | New |
| 11 | STATE STREET CORP | $51.9M | 2.3M | Added |
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $42.5M | 1.9M | New |
| 13 | Polar Capital Holdings Plc | $41.0M | 1.8M | New |
| 14 | Avidity Partners Management LP | $37.8M | 1.7M | Added |
| 15 | Remedium Capital Partners, LLC | $35.1M | 1.6M | Hold |
| 16 | Soleus Capital Management, L.P. | $34.5M | 1.6M | Added |
| 17 | JPMORGAN CHASE & CO | $32.6M | 1.5M | Added |
| 18 | BAKER BROS. ADVISORS LP | $27.3M | 1.2M | Trimmed |
| 19 | Logos Global Management LP | $25.0M | 1.1M | Added |
| 20 | Versant Venture Management, LLC | $22.0M | 991,783 | Trimmed |
| 21 | ACORN CAPITAL ADVISORS, LLC | $21.9M | 986,760 | Added |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | $21.9M | 985,178 | Added |
| 23 | CITADEL ADVISORS LLC | $20.7M | 929,407 | Added |
| 24 | Foresite Capital Management VI LLC | $19.7M | 886,667 | Added |
| 25 | Balyasny Asset Management L.P. | $19.5M | 878,726 | Added |