| 1 | PERCEPTIVE ADVISORS LLC | $17.1M | 1.9M | Hold |
| 2 | ADAR1 Capital Management, LLC | $7.1M | 777,100 | Added |
| 3 | ACORN CAPITAL ADVISORS, LLC | $5.8M | 634,539 | Hold |
| 4 | TCG Crossover Management, LLC | $4.3M | 464,398 | Hold |
| 5 | Commodore Capital LP | $4.3M | 464,398 | Hold |
| 6 | NEA Management Company, LLC | $4.3M | 464,398 | Hold |
| 7 | Kalehua Capital Management LLC | $3.6M | 393,701 | Hold |
| 8 | Spruce Street Capital LP | $3.6M | 393,701 | Hold |
| 9 | Blackstone Inc. | $3.0M | 324,638 | New |
| 10 | VANGUARD GROUP INC | $2.9M | 319,372 | Added |
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.8M | 300,000 | New |
| 12 | Seven Fleet Capital Management LP | $1.4M | 154,153 | Trimmed |
| 13 | Simplify Asset Management Inc. | $1.4M | 149,279 | Hold |
| 14 | Propel Bio Management, LLC | $1.4M | 149,279 | Hold |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $739,513 | 80,418 | Added |
| 16 | BlackRock, Inc. | $727,719 | 79,186 | Added |
| 17 | RENAISSANCE TECHNOLOGIES LLC | $711,527 | 77,424 | Added |
| 18 | BANK OF AMERICA CORP /DE/ | $299,199 | 32,557 | Trimmed |
| 19 | MILLENNIUM MANAGEMENT LLC | $298,216 | 32,450 | Added |
| 20 | Laird Norton Wetherby Trust Company, LLC | $200,508 | 21,818 | Hold |
| 21 | STATE STREET CORP | $150,137 | 16,337 | Hold |
| 22 | DIMENSIONAL FUND ADVISORS LP | $135,351 | 14,728 | New |
| 23 | NORTHERN TRUST CORP | $132,281 | 14,394 | Hold |
| 24 | TWO SIGMA INVESTMENTS, LP | $122,006 | 13,276 | Hold |
| 25 | XTX Topco Ltd | $107,973 | 11,749 | New |