| 1 | FEDERATED HERMES, INC. | $25.9M | 4.7M | Trimmed |
| 2 | Jupiter Topco LLC | $24.3M | 4.4M | New |
| 3 | Vivo Capital, LLC | $24.0M | 4.3M | Hold |
| 4 | Balyasny Asset Management L.P. | $23.6M | 4.3M | Trimmed |
| 5 | Logos Global Management LP | $18.3M | 3.3M | Added |
| 6 | VANGUARD GROUP INC | $13.6M | 2.4M | Added |
| 7 | FARALLON CAPITAL MANAGEMENT LLC | $13.1M | 2.4M | Hold |
| 8 | BlackRock, Inc. | $12.4M | 2.2M | Added |
| 9 | Ally Bridge Group (NY) LLC | $12.1M | 2.2M | Added |
| 10 | Foresite Capital Management VI LLC | $11.0M | 2.0M | Trimmed |
| 11 | Spruce Street Capital LP | $9.2M | 1.7M | Hold |
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $7.9M | 1.4M | Hold |
| 13 | Trails Edge Capital Partners, LP | $7.9M | 1.4M | Hold |
| 14 | Seven Fleet Capital Management LP | $5.6M | 1.0M | Trimmed |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $5.4M | 974,236 | Added |
| 16 | DV EQUITIES, LLC | $4.2M | 754,397 | New |
| 17 | ACUTA CAPITAL PARTNERS, LLC | $3.9M | 709,500 | Hold |
| 18 | MILLENNIUM MANAGEMENT LLC | $3.0M | 533,602 | Trimmed |
| 19 | STATE STREET CORP | $2.4M | 424,915 | Added |
| 20 | NORTHERN TRUST CORP | $1.6M | 292,117 | Added |
| 21 | GOLDMAN SACHS GROUP INC | $798,945 | 143,954 | Added |
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $630,619 | 113,625 | Added |
| 23 | Sixth Street Partners Management Company, L.P. | $630,619 | 113,625 | New |
| 24 | Bank of New York Mellon Corp | $419,468 | 75,580 | New |
| 25 | RENAISSANCE TECHNOLOGIES LLC | $406,815 | 73,300 | Trimmed |