| 1 | Vivo Capital, LLC | $43.7M | 11.4M | Hold |
| 2 | Caligan Partners LP | $30.5M | 8.0M | New |
| 3 | PERCEPTIVE ADVISORS LLC | $24.6M | 6.4M | Added |
| 4 | RA CAPITAL MANAGEMENT, L.P. | $16.9M | 4.4M | Hold |
| 5 | Commodore Capital LP | $16.9M | 4.4M | Hold |
| 6 | Balyasny Asset Management L.P. | $14.4M | 3.8M | Added |
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $13.0M | 3.4M | New |
| 8 | MILLENNIUM MANAGEMENT LLC | $11.6M | 3.0M | Added |
| 9 | Woodline Partners LP | $10.9M | 2.9M | Added |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | $9.6M | 2.5M | New |
| 11 | Spruce Street Capital LP | $8.4M | 2.2M | Hold |
| 12 | Sessa Capital IM, L.P. | $8.4M | 2.2M | Hold |
| 13 | BOOTHBAY FUND MANAGEMENT, LLC | $5.7M | 1.5M | New |
| 14 | AMERIPRISE FINANCIAL INC | $5.7M | 1.5M | Added |
| 15 | Ensign Peak Advisors, Inc | $5.3M | 1.4M | New |
| 16 | Soleus Capital Management, L.P. | $4.0M | 1.1M | New |
| 17 | Propel Bio Management, LLC | $3.9M | 1.0M | Added |
| 18 | Jefferies Financial Group Inc. | $3.5M | 903,094 | Added |
| 19 | Blackstone Inc. | $3.3M | 860,170 | Trimmed |
| 20 | ExodusPoint Capital Management, LP | $2.9M | 768,627 | Added |
| 21 | STEMPOINT CAPITAL LP | $2.9M | 750,000 | Added |
| 22 | Affinity Asset Advisors, LLC | $2.2M | 575,000 | New |
| 23 | Monashee Investment Management LLC | $1.9M | 500,000 | New |
| 24 | MARSHALL WACE, LLP | $1.8M | 463,925 | Added |
| 25 | DV Trading LLC | $1.5M | 400,000 | New |